Acute uric acid nephropathy, chronic urate nephropathy, and uric acid nephrolithiasis are three kidney diseases that have been linked to excessive uric acid. Although the clinical characteristics of these illnesses differ, they all have urate deposition or high uric acid as a common factor.
Patients typically get acute uric acid nephropathy after 1-2 days of starting chemotherapy or soon after presenting with acute neoplastic diseases. The signs that are most often noticed include :
Nausea
Vomiting
Lethargy
Seizures
Pain
Urinary frequency
Dysuria
Hematuria
If you have any of these symptoms visit a Nephrologist to be diagnosed and treated properly.
Underlying disorder that causes elevated uric acid include :
Treatment for leukemia or lymphoma
Seizures or ischemic states
Pregnancy-related preeclampsia
Eclampsia
The setting of cyclosporine use and renal transplantation.
Chronic hyperuricemia and gout
The hereditary enzyme disorder HGRPT deficiency
Acute diarrheal states
The tests listed below can help in acute uric acid nephropathy diagnosis and evaluation :
Blood tests :
Urate levels in the plasma
Azotemia
Hyperphosphatemia
Serum lactate dehydrogenase
Serum uric acid levels
Urine analysis :
Uric acid
Sodium monourate crystals
Urinary uric acid levels
Urate crystals
Urinary uric acid crystals
Uric acid stones
The goal of non-dialysis management is to reduce the plasma urate level and the renal tubule urate concentration.
Xanthine oxidase inhibitors including :
Allopurinol reduces uric acid production while maintaining the manufacture of essential purines.
Febuxostat prevents uric acid production and lowers elevated serum uric acid levels.
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