Acute Colonic Pseudo-obstruction (Acute Megacolon, Ogilvie Syndrome)


Description

Acute colonic pseudo-obstruction (Ogilvie syndrome) is a rare, acquired condition marked by disorders affecting the colon's natural, rhythmic peristalsis contractions. Food and other materials are moved through the digestive system by peristalsis due to the cooperation of muscles, nerves, and hormones. Frequently, the colon is greatly enlarged (dilated). Most patients who experience it are older adults with numerous underlying comorbidities, although it can also appear in apparently healthy patients after suffering a traumatic injury or following surgery. Although colonic dilatation can infrequently reach the rectum, acute colonic pseudo-obstruction (Ogilvie syndrome) mostly affects the cecum and right hemicolon. Acute colonic pseudo-obstruction (Ogilvie syndrome) is an uncommon postoperative complication that affects 0.6% of patients who undergo cardiac surgery and 0.7 to 1.3 % of patients who have burns or undergo orthopedic surgery. Symptoms in surgical patients typically appear five days after surgery on average.

Symptoms

Acute colonic pseudo-obstruction (Ogilvie syndrome) symptoms and severity might differ widely from person to person. Acute colonic pseudo-obstruction (Ogilvie syndrome) may result in severe, potentially fatal consequences. Patients who are hospitalized and have an underlying illness or have recently undergone surgery are more likely to experience the disorder. Common symptoms of acute colonic pseudo-obstruction (Ogilvie syndrome) include abdominal swelling (distention) and bloating, abdominal pain, nausea, and vomiting. Some individuals have a history of chronic, sometimes severe constipation. Abdominal distention usually develops over several days but can potentially develop rapidly within a 24-hour period. Colonic distention can be massive. Additional symptoms that can occur include fever, marked abdominal tenderness, and an abnormal increase in the number of white blood cells often due to infection.


Causes

The exact cause of acute colonic pseudo-obstruction (Ogilvie syndrome) is unclear; it most commonly affects individuals with recent serious medical conditions or surgical procedures.

Diagnostics

Acute colonic pseudo-obstruction (Ogilvie syndrome) is diagnosed based on the presence of distinctive symptoms, a thorough review of the patient's medical history, a comprehensive clinical assessment, and a range of specialized testing to rule out other disorders or determine underlying causes.

      X-ray examination of the colon
      Enema
      Computed tomography


Treatment

There is no specific treatment for acute colonic pseudo-obstruction (Ogilvie syndrome). Supportive therapy, medication (neostigmine), bowel decompression, and surgery are all available as therapeutic options for acute colonic pseudo-obstruction (Ogilvie syndrome). 

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