Brugada Syndrome

The signs of the Brugada syndrome can appear at any age and include:

Ventricular tachycardia (an irregular heart rhythm that begins in the lower chambers of your heart).
Faking out (syncope).
Dizziness.
Trouble breathing
Seizures.
Chest fluttering (can feel like a fluttering or a flip-flopping in your chest).
Atrial fibrillation, a rapid, erratic heartbeat that originates in the upper chambers of your heart.
Cardiac arrhythmia. This could be the first sign of Brugada syndrome and the cause of some newborns and young children passing away as they sleep.
The signs of Brugada syndrome resemble those of numerous different illnesses. Book an appointment with your Cardiologist if you experience any of these symptoms or call the emergency number right away if you experience any chest pain or discomfort.

Approximately 70% of Brugada syndrome sufferers lack a documented genetic mutation. Others, however, have a genetic mutation in at least 18 genes. Your heart's ability to conduct the heartbeat signal is hampered by certain alterations.
Brugada syndrome can occur in people without a genetic mutation as a result of an unknown cause or from medications taken to treat certain mental health diseases or heart problems.
Other conditions, such as fever and heat exhaustion, dehydration, medications that block sodium channels, lithium, tricyclic antidepressants, excessive alcohol use, cocaine, and marijuana usage can all contribute to Brugada syndrome.
Seek immediate medical assistance if you experience fainting and suspect it may be caused by a heart issue.

The majority of Brugada syndrome patients have a typical physical examination. But for a patient who is otherwise healthy, such a test is required to rule out other possible cardiac causes of syncope or cardiac arrest (eg, heart murmurs from hypertrophic cardiomyopathy or from a valvular or septal defect).

Testing for those who may have the Brugada syndrome

12-lead ECG in all syncope patients
Sodium channel blocker drug challenge in syncope patients without a clear cause
Electrophysiologic analysis to determine arrhythmia induction for risk assessment
Laboratory examinations that could help in Brugada syndrome diagnosis

Serum potassium and calcium levels: In patients presenting with right precordial leads ST-segment elevation
Potassium and calcium levels: Brugada syndrome-like ECG abnormalities in patients with hypercalcemia and hyperkalemia
CK-MB and troponin levels: In patients with symptoms associated with an acute coronary syndrome
Genetic testing for a mutation in SCN5A
Imaging studies

Run an MRI or echocardiogram to rule out arrhythmogenic right ventricular cardiomyopathy and to look for other probable arrhythmia causes.
An abnormal electrocardiogram (ECG) result, a test that gauges the electrical activity of the heart, is a key indicator of Brugada syndrome.

Brugada syndrome treatment aims to prevent ventricular arrhythmias and treat them when they occur because there is no known cure for the condition. Quinidine, as well as isoproterenol, may be used as treatment besides amiodarone.
If you have a high risk of ventricular fibrillation, experience fainting spells, or have suffered a cardiac arrest, an implantable cardioverter defibrillator (ICD) may be recommended, and ablation
You might initially not require therapy if your Cardiologist believes your risk of developing a heartbeat that beats dangerously quickly is low.